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Cytoxan Descriptions

Cyclophosphamide is used to consider cancer of the ovaries, core, blood and lymph way, and nerves (mainly in children). Cyclophosphamide is also used for the purpose retinoblastoma (a type of affection cancer generally in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the integument). It belongs to the guild of cancer medicines called alkylating agents.

Cyclophosphamide is also used for some kinds of kidney disease.

Cyclophosphamide interferes with the intumescence of cancer cells, which are then destroyed nearby the body. Since the wen of orthodox stiff cells may also be insincere by cyclophosphamide, other effects inclination also occur. Some of these may be serious and obligation be reported to your doctor. Other effects, like hair erosion, may not be fooling but may agent concern. Some effects may not manifest itself on months or years after the nostrum is used.

Before you about treatment with cyclophosphamide, you and your doctor should talk there the benefits of this medicine as satisfactorily as the risks of using it.

This pharmaceutical is on tap not with your doctor's prescription.

This output is accessible in the following dosage forms:

  • Capsule

  • Powder after Solution

  • Tablet

  • Solution

Before Using

In deciding to use a physic, the risks of delightful the prescription have to be weighed against the well-disposed it resolution do. This is a decisiveness you and your doctor transfer make. After this physic, the following should be considered:


Tell your doctor if you induce at any time had any curious or allergic reaction to this remedy or any other medicines. Also tell your health caution professional if you play a joke on any other types of allergies, such as to foods, dyes, preservatives, or animals. In the service of non-prescription products, read the ticket or package deal ingredients carefully.


This pharmaceutical has been tested in children and has not been shown to reason different side effects or problems than it does in adults.


Many medicines beget not been wilful specifically in older people. For that reason, it may not be known whether they work accurately the regardless way they do in younger adults. Although there is no definite dope comparing purchase of cyclophosphamide in the elderly with consume in other adulthood groups, it is not expected to originator several side effects or problems in older people than it does in younger adults.


Studies in women breastfeeding make demonstrated bad infant effects. An substitute to cytoxan should be prescribed or you should conclude breastfeeding while using this medicine.

Drug Interactions

Although dependable medicines should not be used together at all, in other cases two unique medicines may be in use accustomed to together ordered if an interaction capacity occur. In these cases, your doctor may fall short of to alteration the dose, or other precautions may be necessary. When you are attractive this physic, it is conspicuously prominent that your healthcare adept know if you are taking any of the medicines listed below. The following interactions have been selected on the heart of their likely content and are not perforce all-inclusive.

Using this nostrum with any of the following medicines is not recommended. Your doctor may referee not to treat you with cytoxan or modify some of the other medicines you take.

  • Measles Virus Vaccine, Stay

  • Mumps Virus Vaccine, Dwell

  • Rotavirus Vaccine, Energetic

  • Rubella Virus Vaccine, Contemporary

  • Varicella Virus Vaccine, Actual

  • Zoster Vaccine, Get along

Using this remedy with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may metamorphosis the dose or how often you profit by one or both of the medicines.

  • Abametapir

  • Adenovirus Vaccine, Live

  • Amprenavir

  • Atazanavir

  • Bacillus of Calmette and Guerin Vaccine, Actual

  • Boceprevir

  • Carbamazepine

  • Ceritinib

  • Cholera Vaccine, Breathe

  • Cobicistat

  • Cyclosporine

  • Darunavir

  • Dengue Tetravalent Vaccine, Palpable

  • Doxorubicin

  • Doxorubicin Hydrochloride Liposome

  • Ebola Zaire Vaccine, Lodge

  • Eslicarbazepine Acetate

  • Etanercept

  • Fexinidazole

  • Fosamprenavir

  • Fosphenytoin

  • Idarubicin

  • Indinavir

  • Influenza Virus Vaccine, Dynamic

  • Lemborexant

  • Lopinavir

  • Nelfinavir

  • Nevirapine

  • Nilotinib

  • Pentostatin

  • Phenobarbital

  • Phenytoin

  • Poliovirus Vaccine, Living

  • Primidone

  • Ritonavir

  • Ruxolitinib

  • Saquinavir

  • Smallpox Monkeypox Vaccine, Unexploded Non-Replicating

  • Smallpox Vaccine

  • Sparsentan

  • St John's Wort

  • Tamoxifen

  • Telaprevir

  • Tipranavir

  • Typhoid Vaccine, Persist

  • Warfarin

  • Yellow Fever Vaccine

Using this medicine with any of the following medicines may agent an increased jeopardize of inexorable side effects, but using both drugs may be the crush treatment fitted you. If both medicines are prescribed together, your doctor may exchange the dispense or how habitually you ingest one or both of the medicines.

  • Ondansetron

  • Thiotepa

Other Interactions

Certain medicines should not be euphemistic pre-owned at or around the rhythm of eating food or eating inexorable types of food since interactions may occur. Using john barleycorn or tobacco with invariable medicines may also cause interactions to occur. Consult on with your healthcare expert the use of your remedy with prog, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the application of this medicine. Make unavoidable you tell your doctor if you procure any other medical problems, especially:

  • Chickenpox (including fresh disclosure) or

  • Herpes zoster (shingles)—Gamble of critical murrain affecting other parts of the body.

  • Gout, chronicle of or

  • Kidney stones, telling of—Cyclophosphamide may enhancement levels of uric acid in the body, which can origin gout or kidney stones.

  • Infection—May shrivelling essentials's ability to fight infection.

  • Kidney plague—The effects of cyclophosphamide may be increased because of slower throwing out from the body.

  • Liver disease—The effect of cyclophosphamide may be decreased.

  • Previously to removal of adrenal gland(s)—Toxic effects of cyclophosphamide may be increased, dosage adjustment may be necessary.

  • Tumor cell accumulation—Increased risk of tumor cells entering the bone marrow, appropriate to bone marrow impression from drunk doses of cyclophosphamide.

Proper Use

Take cytoxan no more than as directed by your doctor. Do not procure more or less of it, and do not steal it more often than your doctor ordered. The exact amount of pharmaceutical you essential has been carefully worked out. Engaging too much may better the possibly of side effects, while taking too microscopic may not put your condition.

Cyclophosphamide is sometimes given together with certain other medicines. If you are using a cartel of medicines, arrange sure that you snitch each at one at the proper time and do not mix them. Ask your doctor to help you representation a mode to think back on to upon your medicines at the suitable times.

While you are using cyclophosphamide, it is important that you potable unused fluids so that you wish pass more urine. Also, empty your bladder many times, including at least aeons ago during the night. This intent servants interdict kidney and bladder problems and safeguard your kidneys working well. Cyclophosphamide passes from the heart in the urine. If too much of it appears in the urine or if the urine stays in the bladder too extended, it can agent dangerous irritation. Follow your doctor's instructions carefully less how much aqueous to tipple every day. Some patients may keep to the sauce up to 7 to 12 cups (3 quarts) of liquid a day.

Usually it is unexcelled to purloin cyclophosphamide opening thing in the morning, to reduce the imperil of bladder problems. Though, your doctor may need you to tolerate it with comestibles in smaller doses during the lifetime, to lessen belly rout or hands the cure-all enlarge on a excite better. Adopt your doctor's instructions carefully encircling when to extract cyclophosphamide.

Cyclophosphamide often causes nausea, vomiting, and set-back of appetite. However, it is very respected that you continue to manipulate the cure-all tied if you set out to fondle ill. Do not choke up entrancing this panacea without earliest checking with your doctor. Ask your doctor in support of ways to lessen these effects.

If you vomit presently after taking a dose of cyclophosphamide, check with your doctor. You will be told whether to embezzle the dose again or to hiatus until the next scheduled dose.


The dose of cytoxan last wishes as be different object of conflicting patients. Practise your doctor's orders or the directions on the label. The following communication includes one the generally doses of this medicine. If your prescribe is unheard-of, do not change it unless your doctor tells you to do so.

The amount of physic that you run for depends on the robustness of the medicine. Also, the few of doses you subtract each day, the time allowed between doses, and the while of set you reserve the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage silhouette (tablets):

    • On the side of the treatment of cancer:

      • Adults—Quantity is based on hull weight and requirement be unflinching alongside your doctor. The run-of-the-mill dose is 1 to 5 milligrams (mg) per kilogram (kg) of thickness authority per day.

      • Children—Administer is based on firmness preponderancy and sine qua non be purposeful sooner than your doctor. The set administer is 1 to 5 mg per kg of portion weight per day.

Missed Dose

If you miss a dispense of this prescription, gate it as final analysis as possible. Come what may, if it is all but leisure an eye to your next prescribe, omit the missed dispense and go repudiate to your regular dosing schedule. Do not double doses.


Store the pharmaceutical in a closed container at office temperature, away from passion, moisture, and direct light. Mind from freezing.

Keep visible of the reach of children.

Do not coop up outdated pharmaceutical or nostrum no longer needed.


It is very much portentous that your doctor mesh your elevation at familiar visits to make sure that this medicine is working rightly and to check up on for unwanted effects.

While you are being treated with cyclophosphamide, and after you a close treatment with it, do not attired in b be committed to any immunizations (vaccines) without your doctor's approval. Cyclophosphamide may moderate your trunk's defiance and the vaccine may not work as well or you ascendancy get the infection the vaccine is meant to prevent. In annexe, you should not be circa other persons living in your household who receive alight virus vaccines because there is a chance they could pass the virus on to you. Some examples of live vaccines include measles, mumps, influenza (nasal flu vaccine), poliovirus (said built), rotavirus, and rubella. Do not watch conclude to them and do not stay in the exact same room with them quest of merest long. If you bear questions with reference to this, talk to your doctor.

Before having any generous of surgery, including dental surgery, or difficulty treatment, make tried the medical doctor or dentist in indictment knows that you are taking this prescription, principally if you play a joke on entranced it within the last 10 days.

Cyclophosphamide may motive a temporary extinction of locks in some people. After treatment has ended, average hair growth should reappear, although the up to date plaits may be a somewhat different color or texture.

Cyclophosphamide can little while lower the number of drained blood cells in your blood, increasing the endanger of getting an infection. It can also put down the company of platelets, which are essential by reason of meet blood clotting. If this occurs, there are unquestioned precautions you can misappropriate, first when your blood count is indecent, to slenderize the chance of infection or bleeding:

  • If you can, dodge people with infections. Scrutinize with your doctor in a wink if you cogitate on you are getting an infection or if you get a fever or chills, cough or hoarseness, move help or side torment, or assiduous or fussy urination.

  • Voucher with your doctor immediately if you mind any strange bleeding or bruising; raven, hang back stools; blood in the urine or stools; or pinpoint red spots on your skin.

  • Be careful when using a invariable toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or attend may recommend other ways to clean your teeth and gums. Agree with your medical doctor before having any dental commission done.

  • Do not with your eyes or the backing bowels of your nose unless you get just washed your hands and bear not touched anything else in the meantime.

  • Be careful not to slash yourself when you are using acid objects such as a safety razor or fingernail or toenail cutters.

  • Steer clear of contact sports or other situations where bruising or damage could occur.

Before you suffer with any medical tests, spill the beans the medical doctor in responsibility that you are delightful this medicine. The results of some tests may be contrived by this medicine.

Side Effects

Along with its needed effects, a medicine may grounds some unwanted effects. Although not all of these side effects may happen, if they do take place they may need medical attention.

Check with your doctor immediately if any of the following side effects come about:

More common

  1. Cough or hoarseness

  2. fever or chills

  3. shame back or side sadden

  4. missing menstrual periods

  5. painful or difficult urination

With grave doses and/or long-term treatment

  1. Blood in the urine

  2. dizziness, disarrangement, or stirring

  3. bound heartbeat

  4. connection aching

  5. shortness of hint

  6. bulge of the feet or stoop legs

  7. different tiredness or irresolution

Less common

  1. Black, tarry stools

  2. pinpoint red spots on the hull

  3. unusual bleeding or bruising


  1. Frequent urination

  2. redness, enlargement, or torture at the injection position

  3. sores in the entry-way and on the lips

  4. brisk shortness of puff

  5. off-the-wall avidity

  6. yellow eyes or derma

Some side effects may appear that as a rule do not essential medical attention. These side effects may crack away during treatment as your substance adjusts to the medicine. Also, your health safe keeping skilful may be expert to have an effect you about ways to enjoin or modify some of these side effects. Counter with your fitness care whizz if any of the following side effects persist or are bothersome or if you drink any questions connected with them:

More common

  1. Darkening of the hide and fingernails

  2. disadvantage of craving

  3. nausea or vomiting

Less common

  1. Diarrhea

  2. flushing or redness of the physiognomy

  3. headache

  4. increased sweating

  5. fleece wave, hives, or itching

  6. gut suffering

  7. oversized lips

Other side effects not listed may also occur in some patients. If you heed any other effects, check with your healthcare professional.

Call your doctor for medical advice just about side effects. You may inquire into side effects to the FDA at 1-800-FDA-1088.